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The most reliable way to use Sage right now is with its default Python 2. Before it moves to Python 3, all of the problems will have to be worked out. How frequently you will run into problems, and how serious those problems will be, depends on what you want to do. If you run Sage's doctests, you will see lots of failures, but there are also lots of successes. Running the doctests is one good way to see where there are problems. Just using Sage is another.

This is the best answer that I can give unless you specify how you plan to use Sage — graph theory? simplicial complexes? calculus? something else — and unless you quantify, or at least clarify, what you mean by "worth the trouble".