I don't know if there's such a setting, but here's an idea to get close to what you want: You could put the commands you want in a separate file, which you load at the beginning of each worksheet (you could use %auto to automatically evaluate that cell when you open the worksheet too). At least you wouldn't have to copy and paste a long list of commands for each new worksheet, and if you update the defaults they would be automatically updated for all worksheets.