Certainly an error from my type setting but this code
# Polynomial interpolation
# Passing the matrix
A = Matrix([[0,0],[0.5,0.25],[0.6,0.36],[2,4]])
var('a0, a1, a2, a3, a4')
B =[[A[i][1], a3*A[i][0]^3+ a2*A[i][0]^2+ a1*A[i][0]+ a0] for i in range(0,4)]
C=[[(B[i][0]-B[i][1])^2] for i in range(0,4)]
# sum of the square of errors
ssr=sum(C[i][0] for i in range(4))
# First order condition of optimality
ssr_a0=ssr.diff(a0)
ssr_a1=ssr.diff(a1)
ssr_a2=ssr.diff(a2)
ssr_a3=ssr.diff(a3)
ssr_a4=ssr.diff(a4)
# solution
sol=solve([ssr_a0==0,ssr_a1==0,ssr_a2==0,ssr_a3==0,ssr_a4==0], a0, a1, a2, a3, a4, solution_dict=True)
sol
as the following solution [{a0: 0, a1: 0, a2: 1, a3: 0, a4: r3}]
. Could some one find my mistake ?