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Why is diff(conjugate(x),x) unevaluated?

Or, can we differentiate holomorphic functions only?

Wirtinger defined two derivations in complex analysis for which we have: diff(x,conjugate(x)) = 0 and diff(conjugate(x),x) = 0.

http://en.wikipedia.org/wiki/Wirtinger_derivatives

Wirtinger calculus has important applications in optimization and has been extended to quaternion functions.

Is there any situation in which leaving diff(conjugate(x),x) unevaluated is an advantage?