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You can gain more control on spacing and fonts if you also use the html function and the format method, since then you can employ the resources of the HTML language. Try this:

reset()
var('x t')
Psi = function('Psi')(x, t)
V = function('V')(x)
format_string = '<strong>Instructions</strong><br>Plug ${}$, ${}$ and ${}$ into ${}$'
terms = [latex(i) for i in [Psi, diff(Psi, t), diff(Psi, x, x), V]]
show(html(format_string.format(*terms)))

The output is:

Instructions
Plug $\Psi\left(x, t\right)$, $\frac{\partial}{\partial t}\Psi\left(x, t\right)$ and $\frac{\partial^{2}}{(\partial x)^{2}}\Psi\left(x, t\right)$ into $V\left(x\right)$